Youth overweight a risk factor for blood clots as adult

Date:
March 2, 2023
Source:
University of Gothenburg
Summary:
Being overweight in childhood and in early adulthood are discrete
risk factors for blood clots later in life, a University of
Gothenburg study shows. The study is based on the early BMI history
of more than 37,000 men and information about their thrombi,
if any, in adulthood.


Facebook Twitter Pinterest LinkedIN Email
FULL STORY ========================================================================== Being overweight in childhood and in early adulthood are discrete risk
factors for blood clots later in life, a University of Gothenburg study
shows. The study is based on the early BMI history of more than 37,000
men and information about their thrombi, if any, in adulthood.


==========================================================================
The association between obesity and blood clots is already established.

However, to date it has been unclear how much influence a raised BMI in childhood and puberty exerts. The purpose of the study was to clarify
the links between BMI in early life and subsequent thrombi.

Thrombi usually arise in the legs, often starting in a blood vessel in
the calf. Swelling, pain and redness are common symptoms. Treated early,
clots are seldom dangerous. However, if one breaks loose, is borne to
the lungs in the bloodstream, and adheres to the vessel wall there,
the resulting "pulmonary embolism" may be life-threatening.

The present study comprises 37,672 men in Sweden, born between 1945
and 1961.

It is based on information about height, weight, and BMI from the men's records, first from school health care services (at the age of 8 years)
and, second, from medical examinations on enrollment in the Armed Services
(at age 20), along with register data on any blood clots up to age 62
on average.

Distinctly elevated thrombus risk It emerges from the results, now
published in the Journal of Internal Medicine, that BMI at both ages
8 and 20, independently of each other, can be linked to venous blood
clots. These may occur in, for example, the leg (deep vein thrombosis,
DVT) or the lung (pulmonary embolism).

In adulthood, two groups were found to be at a significantly increased
risk of venous thrombi. The first was individuals who had been overweight
both as children and as young adults, while the second was composed of
those whose weight in childhood was normal and who became overweight
only in early adulthood.

Moreover, being overweight in both childhood and young adulthood was found
to raise the risk of arterial thrombi -- that is, clots resulting from constricted blood vessels with fatty deposits and inflammation. Since
there were few cases of arterial blood clots in the study, however,
further studies are needed to confirm these findings. All comparisons
in the study were made with the control group, whose weight was normal
at both 8 and 20 years of age.

Overweight in puberty an important factor The first and corresponding
author of the study is Lina Lilja, a doctoral student at Sahlgrenska
Academy, University of Gothenburg, and pediatrician. At the time of the
study, she worked at the Kungsho"jd pediatric clinic in Gothenburg. Today,
she is a senior physician in child health care in Region Va"stra
Go"taland.

"Our study shows that both overweight in childhood and overweight in young adulthood increase the risk of venous blood clots later in life. The
latter, overweight when the men were young adults, proved to be a more influential factor than overweight when they were children," Lilja notes.

Professor and senior physician Claes Ohlsson and associate professor
and senior physician Jenny Kindblom, both of Sahlgrenska Academy at the University of Gothenburg and Sahlgrenska University Hospital, were senior authors of the study.

"Obesity and overweight during puberty seem to have a marked impact on
a person's future risks of venous thrombi," Kindblom concludes.

The study includes data from the BMI Epidemiology Study (BEST) in
Gothenburg, a population study, and from Swedish national registers.

* RELATED_TOPICS
o Health_&_Medicine
# Blood_Clots # Obesity # Diet_and_Weight_Loss #
Hypertension # Healthy_Aging # Heart_Disease #
Children's_Health # Anemia
* RELATED_TERMS
o Adolescence o Malignant_melanoma
o Fertility o Personalized_medicine o
Erikson's_stages_of_psychosocial_development o Obesity o
Chemical_synapse o Decade_Volcanoes

========================================================================== Story Source: Materials provided by University_of_Gothenburg. Note:
Content may be edited for style and length.


========================================================================== Journal Reference:
1. Lina Lilja, Maria Bygdell, Jari Martikainen, Annika Rosengren,
Jenny M.

Kindblom, Claes Ohlsson. Overweight in childhood and young adulthood
increases the risk for adult thromboembolic events. Journal of
Internal Medicine, 2023; DOI: 10.1111/joim.13617 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/03/230302093408.htm

--- up 1 year, 3 days, 10 hours, 50 minutes
* Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3)