Time of day may determine the amount of fat burned by exercise

Date:
February 13, 2023
Source:
Karolinska Institutet
Summary:
Physical activity at the right time of the day seems able to
increase fat metabolism, at least in mice. A new study shows that
mice that did exercise in an early active phase, which corresponds
to morning exercise in humans, increased their metabolism more
than mice that did exercise at a time when they usually rest.


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FULL STORY ========================================================================== Physical activity at the right time of the day seems able to increase
fat metabolism, at least in mice. A new study from Karolinska Institutet
in Sweden and the University of Copenhagen in Denmark shows that mice
that did exercise in an early active phase, which corresponds to morning exercise in humans, increased their metabolism more than mice that did
exercise at a time when they usually rest. The results are published in
the journal PNAS.


========================================================================== Physical activity at different times of the day can affect the body in different ways since the biological processes depend on the circadian
rhythms of the cells. To ascertain how the time of day at which exercise
is done affects the burning of fat, researchers at Karolinska Institutet
and the University of Copenhagen studied the adipose tissue of mice after
a session of high-intensity exercise performed at two points of the daily cycle, an early active phase and early rest phase (corresponding to a
late morning and late evening session, respectively, in humans). The researchers studied various markers for fat metabolism and analysed
which genes were active in adipose tissue after exercise.

Independent of food intake The researchers found that physical activity
at an early active phase increased the expression of genes involved
in the breakdown of adipose tissue, thermogenesis (heat production)
and mitochondria in the adipose tissue, indicating a higher metabolic
rate. These effects were observed only in mice that exercised in the
early active phase and were independent of food intake.

"Our results suggest that late morning exercise could be more effective
than late evening exercise in terms of boosting the metabolism and the
burning of fat, and if this is the case, they could prove of value to
people who are overweight," says Professor Juleen R. Zierath from the Department of Molecular Medicine and Surgery and the Department of
Physiology and Pharmacology, Karolinska Institutet.

Improve the health benefits of exercise Mice and humans share many basic physiological functions, and mice are a well- established model for human physiology and metabolism. However, there are also important differences,
such as the fact that mice are nocturnal.

"The right timing seems to be important to the body's energy balance and
to improving the health benefits of exercise, but more studies are needed
to draw any reliable conclusions about the relevance of our findings to humans," says Professor Zierath.

The study was conducted in close collaboration with the Novo Nordisk
Foundation Center for Basic Metabolic Research (CBMR) at the University
of Copenhagen and was financed by the Novo Nordisk Foundation, Novo
Nordisk, the Swedish Diabetes Foundation, the Swedish Research Council
and Karolinska Institutet.

* RELATED_TOPICS
o Health_&_Medicine
# Fitness # Obesity # Diet_and_Weight_Loss #
Staying_Healthy # Men's_Health # Triglycerides #
Medical_Topics # Nutrition
* RELATED_TERMS
o Aerobic_exercise o Anaerobic_exercise o House_mouse o
Physical_exercise o Swimming o Mouse o Health_benefits_of_tea
o Running

========================================================================== Story Source: Materials provided by Karolinska_Institutet. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Logan A. Pendergrast, Leonidas S. Lundell, Amy M. Ehrlich,
Stephen P.

Ashcroft, Milena Scho"nke, Astrid L. Basse, Anna Krook,
Jonas T. Treebak, Lucile Dollet, Juleen R. Zierath. Time
of day determines postexercise metabolism in mouse adipose
tissue. Proceedings of the National Academy of Sciences, 2023;
120 (8) DOI: 10.1073/pnas.2218510120 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/02/230213201040.htm

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