Management researchers prescribe possible remedy in opioid misuse
Date:
April 14, 2022
Source:
University of Texas at Dallas
Summary:
A team of researchers developed a framework that may help clinicians
objectively identify and estimate harms and benefits of opioid
use for pain management.
FULL STORY ==========================================================================
A decision-support framework developed by management science researchers
from The University of Texas at Dallas could help clinicians objectively identify and estimate harms and benefits of opioid use for pain
management.
==========================================================================
In a study published online Feb. 3 in the INFORMS journal Decision
Analysis, Naveen Jindal School of Management researchers explored how clinicians make decisions when prescribing opioids and developed a
quantitative model of the process that incorporates multiple factors.
"The ongoing opioid epidemic has been a serious public health problem,
and prescription opioids play a role in this problem," said Dr. Metin Cakanyildirim, professor of operations management and one of the study's authors. "Opioid drugs are initially prescribed to treat pain, but their
use can potentially lead to adverse effects of drug tolerance, increased sensitivity to pain, dependence, addiction and overdose." According to
the Centers for Disease Control and Prevention (CDC), more than 14,000
people died in 2019 from overdoses involving prescription opioids.
Cakanyildirim and first author Abdullah Gokcinar, a doctoral student
in operations management, were motivated by the opportunity to use
management science tools to manage a nonmonetary process -- pain --
occurring outside business contexts.
To provide an analytical framework for evidence-based opioid prescribing,
they collaborated with pain researchers Dr. Ted Price BS'97, Ashbel Smith Professor of neuroscience in the School of Behavioral and Brain Sciences
and director of the Center for Advanced Pain Studies, and Dr. Meredith
Adams, assistant professor of anesthesiology at Wake Forest School
of Medicine.
========================================================================== Opioid decision-making incorporates recovery time and pain intensity, as
well as gender, age and drug-use history, Gokcinar said. When prescribing opioids, a clinician faces several uncertainties, including opioid
tolerance and hypersensitivity.
CDC guidelines direct clinicians to prescribe the lowest effective dose
of opioids. The agency emphasizes evaluation of trade-offs in opioid
use and directs clinicians to assess pain, check patient opioid history, discuss adverse effects and observe patient cues for drug abuse.
Although recent guidelines loosely limit prescription amounts, the exact prescription decision is left to the clinician, who typically mentally
accounts for the trade-offs of beneficial versus adverse effects.
By quantifying this mental process, the researchers built a framework
that could lead to prescription decision-support tools. The framework incorporates several parameters related to pain and recovery time,
as well as adverse effects such as discomfort, dependence, tolerance
and hypersensitivity.
The analysis found that over- and under-prescribing occur due to clinical uncertainties and lack of estimation and evaluation methods. Accurately incorporating adverse effects into the decision-support framework yields
pain- management models for chronic, acute and persistent pain types.
==========================================================================
The models provide optimal prescriptions to minimize the total pain,
discomfort and suffering, and can reduce overprescribing, Gokcinar said.
"The clinician can measure the patient's pain, approximate its trajectory
and estimate the discomfort during opioid use along with the risk of
addiction or overdose," he said. "Inputting these and other factors
into a decision-support framework that balances benefits and adverse
effects of opioids yields an optimal prescription." Additional Framework Applications Gokcinar said that such a framework could also be adapted
to host patient data, including administered dosages, and to facilitate
the review of a patient's pain treatment, transfer of information back
and forth between clinicians during and after a patient handover, and benchmarking of these treatments across clinics.
The study found that clinicians who initially prescribe opioids
before handing over their patients to another provider are prone to underestimating the adverse effects. A framework could draw a clinician's attention to the adverse effects or limit their prescription until the handover, he said.
"Using this model could pave the road toward frequently prescribing
reduced amounts of opioids and hence adjusting prescriptions -- known
as adaptive treatment -- according to patient statuses," Gokcinar
said. "Without such decision support, clinicians are forced to quickly
come up with good prescriptions by combining their patient observations
with their experiences.
This is not an easy task to perform well repetitively in stressful
settings." For patients, having a framework in place could help them understand that reduced amounts of opioids will maintain the long-term
health of their nervous system.
"That might mean suffering more today to suffer less later," Cakanyildirim said. "Pain management can be a long-term process and requires patients
to be less myopic and more forward-looking." Using real-life data of
daily reported pain levels and opioid use from Flaredown, a mobile app
that helps users track their diseases and medication, the researchers
inferred the timing and severity of adverse effects. Also, using data
from surgery patients in a clinical setting, the researchers compared
the suggestions of their models to clinical practice.
Once the models are validated in a clinical setting, they could
potentially support balanced opioid prescribing. They also could aid policymakers in evaluating prescription policies.
Cakanyildirim said the researchers plan to further their work by
collaborating with medical professionals and pain clinics to study
information conveyed by patient questionnaires, assessments via
telemedicine and adaptive treatment approaches.
========================================================================== Story Source: Materials provided by
University_of_Texas_at_Dallas. Original written by Brittany
Magelssen. Note: Content may be edited for style and length.
========================================================================== Journal Reference:
1. Abdullah Go"kc,ınar, Metin C,akanyıldırım,
Theodore
Price, Meredith C. B. Adams. Balanced Opioid Prescribing via a
Clinical Trade-Off: Pain Relief vs. Adverse Effects of Discomfort,
Dependence, and Tolerance/Hypersensitivity. Decision Analysis,
2022; DOI: 10.1287/ deca.2021.0447 ==========================================================================
Link to news story:
https://www.sciencedaily.com/releases/2022/04/220414110828.htm
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