• Viral transformations in the female geni

    From ScienceDaily@1:317/3 to All on Thu Mar 31 22:30:46 2022
    Viral transformations in the female genital tract can spell trouble for women's health

    Date:
    March 31, 2022
    Source:
    Arizona State University
    Summary:
    A new study uses next-generation gene sequencing to get a clearer
    read on the community of viruses present in vaginal microbiome
    samples and its implication for the development of cervical cancer.



    FULL STORY ==========================================================================
    The human papillomavirus (HPV) is a known risk factor for cervical cancer.

    Researchers at Arizona State University are hoping to better understand
    the factors leading to persistent HPV infection and the progression to
    cancer, by studying the complex communities of microbes in the female reproductive tract, known as the vaginal microbiome.


    ==========================================================================
    In a new study, Efrem Lim and his colleagues examine an often-overlooked
    subset of the vaginal microbiome -- the viruses. Lim is a researcher
    with the ASU Biodesign Center for Fundamental and Applied Microbiomics,
    and an assistant professor at the ASU School of Life Sciences. The
    research demonstrates that crucial changes in the vast community of
    viruses or virome may enable persistent HPV infection and progression
    to cancer. The viral alterations appear to be associated with changes
    in bacterial composition and genital inflammation.

    "Microbes maintain a delicate balance in our body to promote health,"
    Lim says.

    "Viruses can tip the scale towards a worse health outcome." The research appears in the current issue of the journal mSystems.

    Cervical cancer is one of the most common cancers among women. In 2020,
    more than 600,000 cases and 340,000 deaths were reported worldwide. In
    addition to infection with the HPV virus, known risk factors for cervical cancer include immunodeficiency, smoking and oral contraceptive use.

    Recent studies have explored the relationship of the vaginal
    microbiome to cervical cancer, though the viral component has often
    been neglected. Viruses interact with both human cells and the vast
    profusion of bacteria present in the genital tract. The new study uses next-generation gene sequencing to get a clearer read on the community of viruses present in vaginal microbiome samples from women in the Phoenix, Arizona metropolitan area.

    The results highlight an association between genital inflammation and low abundance of the bacterial species Lactobacillus with reduction in virome diversity. Lactobacillus bacteria are known to be important mediators of genital health. Further, conditions conducive to persistent HPV infection
    were also associated with the abundance of a group of viruses that infect bacteria - - known as bacteriophages. The findings further emphasize
    the importance of studies of the virome and its complex interactions
    with other constituents of the human microbiome.


    ========================================================================== Story Source: Materials provided by Arizona_State_University. Original
    written by Richard Harth. Note: Content may be edited for style and
    length.


    ========================================================================== Journal Reference:
    1. Emily A. Kaelin, Peter T. Skidmore, Paweł Łaniewski,
    LaRinda A.

    Holland, Dana M. Chase, Melissa M. Herbst-Kralovetz, Efrem S. Lim.

    Cervicovaginal DNA Virome Alterations Are Associated with Genital
    Inflammation and Microbiota Composition. mSystems, 2022; DOI:
    10.1128/ msystems.00064-22 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/03/220331151530.htm

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