• COVID-19 Increases risk of typediabetes,

    From ScienceDaily@1:317/3 to All on Mon Mar 21 22:30:44 2022
    COVID-19 Increases risk of typediabetes, study finds

    Date:
    March 21, 2022
    Source:
    Deutsches Zentrum fuer Diabetesforschung DZD
    Summary:
    People who have had COVID-19 are at increased risk of developing
    type 2 diabetes, according to a new study.



    FULL STORY ========================================================================== People who have had Covid-19 are at increased risk of developing type
    2 diabetes. This is the result of a study by DDZ, DZD and IQVIA, which
    has now been published in Diabetologia.


    ========================================================================== Studies show that the human pancreas can also be a target of the
    SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2
    virus). Following a Covid-19 infection, reduced numbers of insulin
    secretory granules in beta cells and impaired glucose-stimulated insulin secretion have been observed. In addition, after Covid-19 disease, some patients developed insulin resistance and had elevated blood glucose
    levels although they had no previous history of diabetes. SARS-CoV-2
    infection may lead to a strong release of pro-inflammatory signaling
    substances (cytokines). Activation of the immune system may persist for
    months after a SARS-CoV-2 infection and impair insulin effectiveness
    (muscle, fat cells, liver).

    To date, however, it is unclear whether these metabolic changes are
    transient or whether Covid-19 disease increases the risk of persisting diabetes. To investigate this question, researchers from the German
    Diabetes Center (DDZ), German Center for Diabetes Research (DZD) and IQVIA (Frankfurt) conducted a retrospective cohort study.

    The cohort study included a representative panel of 1,171 physician
    practices across Germany (March 2020 to January 2021: 8.8 million
    patients). Follow-up continued until July 2021. "The aim of our study was
    to investigate the incidence of diabetes after infection with SARS-CoV-2,"
    said first author Wolfgang Rathmann, head of the Epidemiology Research
    Group at the DDZ. As a control group, the researchers selected people
    with acute upper respiratory tract infections (AURI), which are also
    frequently caused by viruses. The two cohorts were matched for sex, age,
    health insurance, month of Covid-19 or AURI diagnosis, and comorbidities (obesity, hypertension, high cholesterol, heart attack, stroke). Patients
    on corticosteroid therapy were excluded from the study.

    During the study period, 35,865 people were diagnosed with Covid-19. "Our analyses showed that patients with Covid-19 developed type 2 diabetes more frequently than people with AURI. The incidence of diabetes with Covid-19 infection was 15.8 compared to 12.3 per 1000 people per year with AURI.

    Statistical analysis resulted in an incidence rate ratio (IRR) of
    1.28. Put simply, this means that the relative risk of developing type
    2 diabetes was 28% higher in the Covid-19 group than in the AURI group," Rathmann said, summarizing the results.

    Although type 2 diabetes is unlikely to be a problem for the vast
    majority of people with mild Covid-19 disease, the authors recommend
    that anyone who has recovered from Covid-19 be alert to the warning
    signs and symptoms, such as fatigue, frequent urination and increased
    thirst and seek immediate treatment.


    ========================================================================== Story Source: Materials provided by Deutsches Zentrum fuer
    Diabetesforschung DZD. Note: Content may be edited for style and length.


    ========================================================================== Journal Reference:
    1. Wolfgang Rathmann, Oliver Kuss, Karel Kostev. Incidence of newly
    diagnosed diabetes after Covid-19. Diabetologia, 2022; DOI:
    10.1007/ s00125-022-05670-0 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/03/220321115835.htm

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