COVID-19 Increases risk of typediabetes, study finds
Date:
March 21, 2022
Source:
Deutsches Zentrum fuer Diabetesforschung DZD
Summary:
People who have had COVID-19 are at increased risk of developing
type 2 diabetes, according to a new study.
FULL STORY ========================================================================== People who have had Covid-19 are at increased risk of developing type
2 diabetes. This is the result of a study by DDZ, DZD and IQVIA, which
has now been published in Diabetologia.
========================================================================== Studies show that the human pancreas can also be a target of the
SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2
virus). Following a Covid-19 infection, reduced numbers of insulin
secretory granules in beta cells and impaired glucose-stimulated insulin secretion have been observed. In addition, after Covid-19 disease, some patients developed insulin resistance and had elevated blood glucose
levels although they had no previous history of diabetes. SARS-CoV-2
infection may lead to a strong release of pro-inflammatory signaling
substances (cytokines). Activation of the immune system may persist for
months after a SARS-CoV-2 infection and impair insulin effectiveness
(muscle, fat cells, liver).
To date, however, it is unclear whether these metabolic changes are
transient or whether Covid-19 disease increases the risk of persisting diabetes. To investigate this question, researchers from the German
Diabetes Center (DDZ), German Center for Diabetes Research (DZD) and IQVIA (Frankfurt) conducted a retrospective cohort study.
The cohort study included a representative panel of 1,171 physician
practices across Germany (March 2020 to January 2021: 8.8 million
patients). Follow-up continued until July 2021. "The aim of our study was
to investigate the incidence of diabetes after infection with SARS-CoV-2,"
said first author Wolfgang Rathmann, head of the Epidemiology Research
Group at the DDZ. As a control group, the researchers selected people
with acute upper respiratory tract infections (AURI), which are also
frequently caused by viruses. The two cohorts were matched for sex, age,
health insurance, month of Covid-19 or AURI diagnosis, and comorbidities (obesity, hypertension, high cholesterol, heart attack, stroke). Patients
on corticosteroid therapy were excluded from the study.
During the study period, 35,865 people were diagnosed with Covid-19. "Our analyses showed that patients with Covid-19 developed type 2 diabetes more frequently than people with AURI. The incidence of diabetes with Covid-19 infection was 15.8 compared to 12.3 per 1000 people per year with AURI.
Statistical analysis resulted in an incidence rate ratio (IRR) of
1.28. Put simply, this means that the relative risk of developing type
2 diabetes was 28% higher in the Covid-19 group than in the AURI group," Rathmann said, summarizing the results.
Although type 2 diabetes is unlikely to be a problem for the vast
majority of people with mild Covid-19 disease, the authors recommend
that anyone who has recovered from Covid-19 be alert to the warning
signs and symptoms, such as fatigue, frequent urination and increased
thirst and seek immediate treatment.
========================================================================== Story Source: Materials provided by Deutsches Zentrum fuer
Diabetesforschung DZD. Note: Content may be edited for style and length.
========================================================================== Journal Reference:
1. Wolfgang Rathmann, Oliver Kuss, Karel Kostev. Incidence of newly
diagnosed diabetes after Covid-19. Diabetologia, 2022; DOI:
10.1007/ s00125-022-05670-0 ==========================================================================
Link to news story:
https://www.sciencedaily.com/releases/2022/03/220321115835.htm
--- up 3 weeks, 10 hours, 51 minutes
* Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3)